New study by Haydon lab indicates that astrocytes play a role in stroke

A new study recently published by GliaCure President Phil Haydon’s research lab at Tufts University indicates that astrocytes play a vital role in the spread of damage after stroke. This study, published in The Journal of Neuroscience, suggests that, while researchers have previously focused on the role of neurons and their release of neurotransmitters in…more »



Gliotransmission modulates baseline mechanical nociception

Abstract – Pain is a physiological and adaptive process which occurs to protect organisms from tissue damage and extended injury. Pain sensation beyond injury, however, is a pathological process which is poorly understood. Experimental models of neuropathic pain demonstrate that reactive astrocytes contribute to reduced nociceptive thresholds. Astrocytes release “gliotransmitters” such as D-serine, glutamate, and…more »



Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice.

Abstract – Sleep deprivation (SD) can have a negative impact on cognitive function, but the mechanism(s) by which SD modulates memory remains unclear. We have previously shown that astrocyte-derived adenosine is a candidate molecule involved in the cognitive deficits following a brief period of SD (Halassa et al., 2009). In this study, we examined whether…more »