On May 15, 2012 Health and Human Services Secretary Kathleen Sebelius announced new funding initiatives to aid in the fight against Alzheimer’s disease. The plan, presented at the Alzheimer’s Research Summit 2012, includes funding of new research projects, tools for clinicians, easier access to information for caregivers and an awareness campaign.
GliaCure will be participating in the 2012 BIO International Convention, June 18-21 at the Boston Convention & Exhibition Center, MA. Owners Phil Haydon and Mike Szulczewski will be available to meet with company representatives interested in GliaCure’s research and drug development and to discuss potential partnering opportunities.
GliaCure announced that it has closed its first round of funding. The announcement was published on the MassBio site.
Abstract – Astroglial cells, due to their passive electrical properties, were long considered subservient to neurons and to merely provide the framework and metabolic support of the brain. Although astrocytes do play such structural and housekeeping roles in the brain, these glial cells also contribute to the brain’s computational power and behavioural output. These more…more »
Abstract – Pain is a physiological and adaptive process which occurs to protect organisms from tissue damage and extended injury. Pain sensation beyond injury, however, is a pathological process which is poorly understood. Experimental models of neuropathic pain demonstrate that reactive astrocytes contribute to reduced nociceptive thresholds. Astrocytes release “gliotransmitters” such as D-serine, glutamate, and…more »
Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice.
Abstract – Sleep deprivation (SD) can have a negative impact on cognitive function, but the mechanism(s) by which SD modulates memory remains unclear. We have previously shown that astrocyte-derived adenosine is a candidate molecule involved in the cognitive deficits following a brief period of SD (Halassa et al., 2009). In this study, we examined whether…more »