GliaCure closes on first funding
GliaCure announced that it has closed its first round of funding. The announcement was published on the MassBio site.
25
Apr
2012
22
Mar
2012
Astroglial excitability and gliotransmission: An appraisal of Ca2+ as a signaling route
Abstract – Astroglial cells, due to their passive electrical properties, were long considered subservient to neurons and to merely provide the framework and metabolic support of the brain. Although astrocytes do play such structural and housekeeping roles in the brain, these glial cells also contribute to the brain’s computational power and behavioural output. These more…more »
02
Dec
2011
Gliotransmission modulates baseline mechanical nociception
Abstract – Pain is a physiological and adaptive process which occurs to protect organisms from tissue damage and extended injury. Pain sensation beyond injury, however, is a pathological process which is poorly understood. Experimental models of neuropathic pain demonstrate that reactive astrocytes contribute to reduced nociceptive thresholds. Astrocytes release “gliotransmitters” such as D-serine, glutamate, and…more »
11
May
2011
Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice.
Abstract – Sleep deprivation (SD) can have a negative impact on cognitive function, but the mechanism(s) by which SD modulates memory remains unclear. We have previously shown that astrocyte-derived adenosine is a candidate molecule involved in the cognitive deficits following a brief period of SD (Halassa et al., 2009). In this study, we examined whether…more »